Prescription drug interactions with cannabis

I often get asked how prescription drugs interact with cannabis, and, while I’m no medical expert, I did a little web spelunking today to see if I could at least find some good resources about it.


Cannabis science in the United States isn’t very well developed. Hopefully as legalization spreads we’ll see more studies out there from universities and unbiased research groups.

That said, as I was looking around I found a really great resource on Drugs.com.

You can actually look up drugs that interact with cannabis – or input the prescription drugs you’re on and find out if they interact – here: http://www.drugs.com/drug-interactions/cannabis-index.html

The site has information on 552 types of drugs that cannabis may interact with. Of those, 545 of the interactions are considered “moderate” and seven are considered major.

Those seven are:

acetaminophen / propoxyphene (propoxyphene is the problem component, acetaminophen without propoxyphene isn’t on the list)

aspirin / caffeine / propoxyphene (propoxyphene is the problem component, asprin and caffiene without propoxyphene aren’t on the list)


buprenorphine / naloxone

levomethadyl acetate


sodium oxybate

The site also notes that mixing marijuana and alcohol isn’t advisable. Here’s the site’s interaction information about that: Alcohol and cannabis

WebMD also has some information about interactions here: http://www.webmd.com/vitamins-supplements/ingredientmono-947-marijuana.aspx?activeingredientid=947&activeingredientname=marijuana


Hope this helps!


-SueVo (sue.vorenberg@columbian.com)

Want to comment? Let us know what you think on our Facebook Page or Twitter!